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Glonoin - Appendix symptoms - T.F. Allen

Nitro-glycerine, Spirits Glycerinus Nitrate, Glonoine, Glonoinum, Glon.


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HPUS indication of Glonoin: Throbbing
Common symptoms: Throbbing, Headache, Flushed, Itching, Nausea.

Below are the main rubriks (i.e strongest indications or symptoms) of Glonoin in traditional homeopathic usage, not approved by the FDA.


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APPENDIX

Appendix

Six provers first ascertained their normal pulse, then excited it by running at their utmost speed for about five minutes out of doors; immediately on returning to the room each prover's pulse was counted by another person, and at the same time, just as the counting began, four provers each took a drop of Glonoin in a teaspoonful of water. In five minutes the pulse of each prover was again counted; the result, as exhibited by the table, shows the pulse of the two who took no Glonoin to have been reduced 10 and 14 beats respectively; while the pulse of the other four who took Glonoin after running was reduced 40, 56, 56, and 14 beats respectively. So far the result agrees with that obtained by Dr. Hering. But the experiment shows also, certain undulations of the pulse. This was counted again ten or fifteen minutes after running. No. 1, who took no Glonoin, shows the pulse to have risen to 104 beats, after having previously sunk to 100. No. 2, without Glonoin, shows a steady decline from 125 to 88. No. 3, with Glonoin, shows a steady decline from 140 to 88. in five and ten minutes. No. 4, with Glonoin, shows a decline from 144 to 88 in five and ten minutes, and then a rise to 96 in fifteen minutes. No. 5 was still more remarkable in this respect, showing a rapid diminution of pulse, from 176 to 120 in five and to 104 in ten minutes, and then a rise up to 116 in ten minutes. Prover No. 6 showed a gradual decline. We have then a falling and rising of pulse, after severe exercise, without Glonoin, but the falling and rising is much more marked in two out of four provers who took Glonoin. The next table exhibits the effects of Glonoin on the pulse of eight provers, without preceding exercise.

Authorities

(135 and 136, from Berridge, Hom. World; vol. xiii, p. 401); 135, Dr. George Harley, Med. Times and Gaz., 1858, vol. xvi, p. 356, experiments; 136, Mr. F. A. James, ibid., p. 383, experiment; 137, Allinson, Times, July 31st (Pharm. Journ., 1866-7, p. 263), a man drank a quantity; 138, Conrad Wesselhoeft, M.D., North Amer. Journ. of Hom., New Ser., vol. vii, 1876, p. 6, experiments.

I touched my tongue with the cork moistened with the 1st cent. dil., but experiencing no effects beyond that which usually follows the application of Alcohol or Ether to the tongue, I put 2 drops into my mouth At first I felt a kind of sweet and burning sensation, and soon afterwards a sense of fulness in head and slight tightness about throat, but without nausea or faintness. In a minute or two these effects went off, and could not help thinking that they were partially due to imagination. I now took 5 drops more, and as these did not cause any increased uneasiness, I took in the course of a few minutes 10 more drops. Being at the time quite alone, I became somewhat alarmed lest I should have taken an overdose, and very soon my pulse rose to above 100. The fulness in head and constriction in throat I thought were more marked than before. In a minute or two my courage returned, and the pulse soon fell to 90. The fulness in head lasted some time, and was followed by a slight headache. I took a drop of pure Glonoin by degrees, and found that on bringing it in contact with the tongue it at first gave rise to a sweet flavor, which was rapidly followed by a most disagreeable acrid burning sensation, lasting several minutes. Immediately after taking the drop the pulse was 105. I imagined, too, that I felt fulness in head and some tightness about, throat; but as the effects gradually passed off in the course of a few minutes, I thought they were most probably due to fear and imagination. March 29th, at 12.45 P.M.; my pulse being 80 and my breathing 22, I took a solution containing 1 part of Glonoin to 6 3/4 of spirit, a quantity equal to 1/6 drop of pure Glonoin. At 1 P.M. pulse was 90. I felt some fulness in head and slight tightness about throat. At 1.5 P.M. I took 1/3 drop of pure Glonoin. In three minutes more pulse was 98. At 1.16 P.M. I took 1/2 drop, and in four minutes afterwards, my attention having been directed to another subject, the pulse was 94. At 1.30 P.M. I took a drop of pure Glonoin, and in six minutes the pulse was 106. In ten minutes more, when I had become convinced that I ran no risk, the pulse fell to 78, the breathing being 18. The effect on the heart's action I consider to be entirely due to fear. The head and neck symptoms are too constant to be attributed to the same cause, though I have no doubt the imagination exaggerates them,

I took a minim of Glonoin, my pulse being 80. Half an hour before I had seen my brother take the same dose without any serious effect, and we now purposely changed the subject of conversation. In the course of a few minutes I exclaimed, "I feel drunk." This sensation was quickly followed by a dull aching pain at back of head, which was alternately better and worse, each accession becoming more and more severe. It soon extended to the forehead and the back of the neck, in which there was a decided feeling of stiffness. There was also some difficulty of swallowing, succeeded by nausea, retching, and flatulence. A profuse perspiration ensued, and in fifteen minutes the symptoms began to abate, but I continued dull and heavy. My pulse was now 100. Considerable headache remained, which increased in the afterpart of the day to such an extent that, at 6 P.M., I was compelled to go to bed. At daybreak I was not relieved, but after a few hours more sleep I arose in my usual health,

Was instantly seized with great pain, and his body became diffused with a dark-blue tinge. The unfortunate man only survived a few hours,

The Glonoin used was the dilute nitroglycerin of commerce in proportion of 1 to 80.

Table I.

Table I.

Table II.

Table II.

Eight provers, five women and three men after ascertaining their normal pulse during rest, took 1 or 2 drops of Glonoin, and then counted the pulse every five minutes; the result was remarkable. The pulse of No. 1 sank from 88 to 86, and then to 84, as also observed by Dr. Hering. Nos. 2, 3, and 4 showed a rise after five minutes. No. 5 showed first a falling in five minutes, then a rise after ten minutes. No. 6 showed a rapid fall after two minutes, a rise in five, and a fall again in ten minutes. No. 7, having taken 2 drops, showed a decided fall in five minutes, and a rise in ten minutes. No. 8, like No. 1, after two drops, showed a decline both in five and ten minutes. Aside from the probable homoeopathic effect, we see in Table I that in two out of four instances (Nos. 4 and 5) there is a depression preceding a rise in the pulse, under the effect of Glonoin given during excitement by running. And Table II shows four out of eight provers to have experienced a gradual increase of the pulse, and four others a very marked decline immediately after the medicine. This shows clearly in both tables that the primary action of Glonoin may be depression as well as elevation of the pulse. And we would be justified in drawing the inference that all other symptoms are liable to exhibit such a fluctuation, illustrating how in one or in different individuals the same drug may produce opposite effects, which are not necessarily primary or secondary.

Table III.

Table III is introduced to show that the pulse, having subsided after exercise, and having been excited again soon afterwards by a second effort, will be reduced by Glonoin. This was the case with three provers out of five. In Nos. 1, 3, and 6 the pulse was reduced lower in eight minutes after Glonoin than it was without it. This most probably finds its explanation in Table II, showing that the primary effect may be both diminished and increased action of the pulse, according to the individuality of the prover. It will therefore not always act homoeopathically. Supposing, for instance, the prover to be one whose pulse is primarily depressed by Glonoin, it is then possible that the prover's pulse, when increased by running, would not be met by Glonoin homoeopathically, but antipathically; for it may be found higher eight minutes after glonoin was taken during arterial excitement, than it was eight minutes after such excitement without the Glonoin. If homoeopathic, it should have reduced the pulse more quickly than it would have subsided of its own accord. The instance is illustrated by Nos. 2 and 4 of Table III. It is to be hoped that the subject will be established by further experiments.

Table IV.

Table IV shows very similar results, illustrated by a larger number of counts. The columns of Series I show a steady decline of the pulse after running without Glonoin; while the columns of Series II show a decidedly irregular falling and rising of the pulse, which first diminishes, then increased and finally diminishes again. This was the case with provers 1, 2, and 5. No. 1 had after excitement and Glonoin a diminution of pulse, till in eight minutes it rose from 102 to 108, then fell off again in ten minutes. No. 2, after a decided fall of pulse to 88 in three minutes, had an increase to 100 in four minutes, then a gradual decline. And No. 5, after having his pulse diminished to 92 in four minutes, had an increase to 96 in five minutes, and 104 in six and eight minutes, before falling to 100.

It Will be observed that prover No. 2, whose pulse was primarily depressed in Table II, showed considerable fluctuation in Table IV; he is the only prover who appears in both tables. So far we are able to conclude that the conditions of a prover may vary at different times, showing different results from the same experiment. Furthermore, that Glonoin may raise the pulse at once in some provers, and that it may primarily diminish it in others before elevating, it during the quiescent condition of provers (Table II), and that it will affect it in a similar manner when the pulse has been excited by exercise (Table IV).

Though in a fair number of cases Glonoin will diminish the pulse quicker after its excitement by exercise than it would diminish without Glonoin, we also learn by Table IV that such homoeopathic diminution does not always occur, but that the pulse may sink even more slowly under Glonoin than without it, as also shown by provers 2 and 4 in Table III.

Another purely physiological effect is also apparent, when provers excite the pulse by running a second time in ten or fifteen minutes. It will then be slower to sink under Glonoin than if only one effort to excite the pulse had been made, as in Tables I and III.

The dose is also a matter of importance. In the above experiments drop doses of the tincture (1.80) were used, and it was observed several times that increase of dose caused differences of results; thus in Table II provers 7 and 8 had 2-drop doses, followed by rapid primary depression; these were men. Two women (Nos. 1 and 5), taking only 1 drop, experienced from it the same effect as the men did from 2 drops.

Experiments are yet wanting to determine if higher attenuations will diminish the pulse quicker and with more certainty after running than the drop doses of tincture used by the provers above named, and which failed in Table IV to produce a constant decline, but tended rather to elevate the pulse.

As for Glonoin as a substance, it is one of those whose active qualities are not latent or difficult to develop. Like its new relative, Nitrite of amyl, it acts more quickly upon the organism than most other substances. It is therefore well adapted to proving, and to illustrate to novices the effects of drugs upon the body,

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