Physostigma - General symptoms

GENERAL

General

(Morning), Early, symptoms,.

exhilarated. headache, with epistaxis.

constriction around top of head.

9 A.M., pain in forehead.

before rising, dull headache in forehead.

on awaking, dull frontal headache.

early, lateral headache.

eye symptoms, with burning of the balls.

7 A.M., on rising, darting pains in both eyes.

mydriasis. itching of left nostril, with moisture.

tired look. teeth felt rough.

on waking, taste in mouth like creosote.

bad taste. on waking, nausea.

pain in region of liver.

4 A.M., on rising, soreness in left side of abdomen.

uneasiness in bowels. 4 A.M., griping pain in bowels.

7.30 A.M., before stool, pain in abdomen.

offensive breath. pain in left of sacrum.

7 A.M., shooting pain in left shoulder.

7.30 A.M., trembling of the hands.

8 A.M., confused feeling.

early, till 2 P.M., drowsiness.

while riding, drowsiness, sleepiness.

early, sleep disturbed by lascivious dreams.

on waking, perspiration over whole body..

(Forenoon), 8 A.M., dull heavy feeling in head.

8 and 10 A.M., dull headache.

8 A.M., heavy headache.

congestive headache. while walking, pain in head, with dizziness.

10.15 A.M., headache in left frontal region.

10 A.M., heavy frontal headache.

11 A.M., while in church, aching in temporal region.

shooting pains through right side of head.

11 A.M. to 8 P.M., drawing-twisting sensation in eyes.

eyes bloodshot and burning.

11 A.M. to 8 P.M., partial deafness.

9.30 A.M., pricking sensation in stomach.

sharp pains in stomach.

10.30 A.M., soreness at pit of stomach.

9.50 A.M., pain in left hypochondrium, thigh, and forearm.

10.25 A.M., pain in region of liver.

10 A.M., griping pain in transverse colon.

8.10 A.M., diarrhoeic stool, with burning at the anus.

secretion of urine. with difficult retention.

erections, without sexual desire.

in fresh bracing air, choking sensation, with fluttering of the heart.

11 A.M., burning-throbbing sensation in left arm and hand.

pain in left wrist. 11.30 A.M., numbed sensation in hands.

9 A.M., pain in lower limbs.

weakness in right knee.

gnawing sensation in left tibia.

9.30 A.M., trembling all over.

10.30 A.M., trembling of the hands.

9 and 11.30 A.M., drowsy.

10 A.M., dry, hot skin..

(Afternoon), 4.30 P.M., vertigo and nausea.

1 P.M., on moving, dizziness.

till 10 P.M., pain in head.

headache. 5 P.M., headache.

2 P.M., headache and pain in eyes.

1 P.M., pain in forehead.

4 P.M., on motion, exercise, or mental exertion frontal headache.

pain over right eye. 3 P.M., aching pain over left eye.

2 P.M., headache over right eye.

4 to 10 P.M., headache, with qualmishness.

1 P.M., headache over left eye.

2 P.M., dull frontal headache.

5 and 8 P.M., weight over eyes.

4 P.M., pain through temples, with throbbing of the arteries of the side of the neck.

numbness of the temples and crawling sensation over the head.

1 P.M., headache in temporal region, with sleepiness.

2 P.M., eyes dull and heavy.

3 P.M., drawing-twisting sensation in eyes.

4 P.M., twitching of upper lids.

3 P.M., shooting pain in left ear.

2 and 8 P.M., sensation as if nose were going to bleed.

itching of left nostril.

with dryness. 4 P.M., tongue sore on tip and rough.

6 P.M., collection of mucus in throat.

2 P.M., soreness in throat.

4 to 10 P.M., throat sore, studded with ulcers.

3 P.M., when swallowing, pain extending from throat to left ear.

thirst. 4 P.M., eructations.

5 to 8 P.M., hiccough.

3 P.M., sense of emptiness and weakness in stomach.

6 P.M., soreness in the umbilicus.

3 P.M., looseness in bowels.

pain in abdomen. 4.30 P.M., cutting pain in abdomen.

5.50 P.M., bowels feel uneasy.

6 P.M., pain in groin.

2 P.M., pain extending from left hip into groin.

3 P.M., sensation of fulness and distension of the bladder.

urine high-colored and smelling strong.

4 P.M., leucorrhoea and weakness.

6 P.M., dry cough. 5 P.M., sticking pain in apex of right lung.

6 P.M., soreness around the body, at the waist.

3.45 P.M., pains beneath clavicle.

pain at base of brain.

2 P.M., pain in back. 1 P.M., stiffness and pain down spine.

while sitting, pain under right shoulder-blade.

6.30 P.M., pain in back, between hips.

pain in left of sacrum, 5 P.M., numbness of left forearm, with pain.

pain. pain in right wrist.

2 P.M., pain in right knuckles.

6.30 P.M., weakness of legs.

6 P.M., left hip and right knee stiff.

when walking, stiffness in both rectifemoris muscles.

6.30 P.M., sensation as of a drawing of cords behind leg and knee.

2 and 6 P.M., gnawing sensation in left tibia.

sense of fatigue. 4 P.M., weakness and leucorrhoea.

1 P.M., languid feeling.

just before 6.30 P.M., sudden access of vigor.

nervous motions through body, with palpitation of the heart.

3 P.M., sleepy. 2 P.M., chilly creepings up back, with nausea.

feverish. heat in head.

face hot and flushed..

(Evening), 7 P.M., all symptoms,.

in passing people, dizziness.

7 P.M., head feels stupefied.

headache. 7 and 8 P.M., headache.

8 P.M., frontal headache.

dull frontal headache.

6 P.M., drawing sensation in eyes.

eyes sore and painful when moved.

61/2 to 10 P.M., pain in right eyeball.

10 to 12 P.M., pain in right supraorbital ridge.

7 P.M., on studying, darting pain in left eye and superciliary ridge.

pain and stitches of ball of right eye.

7 P.M., twisted sensation in right eyeball.

8 P.M., twisted sensation in the eyeballs.

uncomfortable sensation in right ear.

6.45 P.M., sharp shooting pain in right ear.

7 P.M., buzzing and ringing ear.

hammering in right ear.

external ear felt as through hot air were blowing on it.

9 P.M., partial deafness in right ear.

itching of left nostril, with moisture.

8 P.M., twitching of the mouth and eyebrows, etc.

9 P.M., roof of mouth feels as if covered with patches of loose skin, and has a yellowish appearance.

metallic taste in mouth.

swallowing of saliva painful.

throat sore. tonsils and soft palate inflamed.

7 and 8 P.M., throat sore.

10 P.M., throat dry. when swallowing, constricted feeling of throat.

9 P.M., scrapy burning sensation in throat.

desire for cold water.

7 P.M., empty eructations, 8.30 P.M., hiccough.

9 to 11 P.M., hiccough.

10 P.M., nausea. rumbling in bowels.

8.40 to 11 P.M., rumbling and gurgling, with heat, in abdomen.

8.30 P.M., rattling in abdomen.

colicky pains low down in abdomen.

8 P.M., pain in groin, with swelling.

7 P.M., pain in groin.

profuse urine. highly colored and strong-smelling.

10 P.M., dyspnoea. 7 P.M., pain in right side.

chilly creeping sensation passing up back.

8 and 9 P.M., numbness over back of head and down spine.

8 P.M., pain in left shoulder.

7 P.M., numbness in left arm and ring finger.

8 P.M., pain in muscles of right forearm.

8 P.M., pain in left wrist.

while in warm room, cramp in left foot.

10 P.M., restless in bed.

chilly. 8 P.M., chills, with frontal headache.

heat in face and back.

8 P.M., skin moist..

(Night), Dizziness.

constriction around top of head.

3 A.M., pressive headache.

aching of eyelids and inner canthus of right eye.

after lying down, singing.

2 A.M., awakened by pressive pain in epigastrium.

on awaking, hiccough. pain in region of arch of colon.

pain in right deltoid muscle.

uneasiness and distress about heart.

woke with rapid tumultuous action of the heart.

after 3 A.M., dragging pain over left hip.

dart of pain through right thumb.

restless sleep. horrid dreams..

(Walking), Dizziness.

headache. shooting pains through right side of head.

vision hazy or misty. piles painful.

on raising foot, floating-like feeling.

on foot touching ground, shuddering sensation.

unsteadiness from knees downwards.

pain in left thigh and both knees.

stupid giddy feeling, with sensation of feebleness.

became very tired..

In five minutes he felt as if he had drank a glass of liquor.

the head was confused, there was vertigo, and the legs lost their strength.

he staggered like a drunken man, and went to bed with his head swimming. He fell asleep, but woke repeatedly through the night with terrible thoughts.

he feared he was becoming crazy, and that he might get up and do some mischief,.

A slight giddiness, which occurred in fifteen minutes, was ascribed to the force of the imagination, and I proceeded to take a warm shower-bath, which process, with the subsequent scrubbing, might take five or six minutes more.

the giddiness was then very decided, and was attended with the peculiar indescribable torpidity over the whole frame which attends the action of Opium and Apocynum Cannabinum ^{Indian hemp} in medicinal doses. I now swallowed the shaving water which I had just been using, by which the stomach was effectually emptied. Nevertheless, I presently became so giddy, weak, and faint that I was glad to lie down supine upon the bed. On getting up, after a tolerable dinner, I was so giddy as to be glad to betake myself to the sofa for the evening (after 12 grains),.

(During the afternoon, a severe attack of my habitual headache set in (had a sunstroke about seven years ago, and since then the left frontal and temporal region is liable to severe pressing-boring pain, as if a coal of fire were imbedded there, and the heat radiating to all sides; the veins of the forehead are swollen and stand out prominently), steadily increasing towards evening), (second day).

(old headache moderately on left side), (sixth day),.

(While travelling, in the cars, had an attack of the customary headache, which lasted from noon till late at night; pain and throbbing in the forehead, worse on moving; irresistible desire to sleep; soporific sleep, extremely distressing; paleness of the face; the sleepiness he never had before; the face was pale, and the attack was unusually severe), (second day),.

Sudden attack of headache, with nausea and bitter rising, followed by dull pain under the sternum.

it was increased by suddenly turning the head, bending forward, or throwing the shoulders forward. On auscultation, heart's action was found to be retarded, with diminished impulse.

rate, 56. there were no abnormal sounds, but the radial pulse was very irregular and weak. He thinks the symptoms may have come from a strain he had about a month ago, in lifting a heavy weight, as he had a similar feeling at the time.

he lifted moderately the same day he took the medicine, but was unaware of any strain at the time (third day),.

(Have been suffering from a dull pressing headache for nearly six months; comparatively free from it in the morning, on rising, but increased by the least mental exertion, until at night, after retiring, it would become almost unbearable; accompanying the pain were sleeplessness and inability to stop thinking; in the course of an hour or two, the headache would pass away suddenly, with a sharp radiating flash of pain, sometimes starting from the occiput and passing forward, at other times passing from before backwards; this headache I found to disappear after taking this medicine),.

After taking the medicine, in the morning, fasting, there was a feeling of constriction around the entire top of the head, as if a tight cap were being pressed down as far as the temples.

at the same time there was a severe pressure along the sagittal suture, as if from fulness in the longitudinal sinus, and dull aching in each temple.

similar effects appeared each night and morning, about fifteen minutes after taking the medicine,.

Headache in left frontal region, with sensation of heat in the abdomen, and slight nausea, at 10.15 A.M.

headache continues, but dull and heavy, at 11.15 A.M.

headache has become general over the whole head, with qualmishness and slight perspiration over the body, at 4 P.M.

headache continues, with qualmishness, at 10 P.M. (second day). Headache less, in the morning.

has continued nearly all day, with lame bruised feeling in the region of kidneys (third day),.

Awoke with headache in left frontal region, which afterwards extends all over the head.

the pain is of a dull heavy character.

at 1 P.M. the headache still continues, but seems to increase in the left frontal region.

at 10 P.M., still continues.

can hardly sit up (second day). The headache is the worst I ever had.

cannot study for the pain in my head.

not so tormenting, at 10 P.M. (third day). Headache, dull, heavy.

began in left frontal eminence.

extended deep into brain.

headache, when walking in the open air, lying down.

could not study (fourth day),.

In church, had a dull aching in temporal and frontal regions, at 11 A.M.

in the evening, the sound of the organ caused the return of headache.

slight headache until retiring, worse in frontal and temporal region (second day). Same headache, only more intense, with such sleepiness that the effort to keep awake produced nausea, at 1 P.M.

this headache did not abate until about 6 P.M. (fourth day). Headache still occasionally but very slight, and sleepiness, as before (fifth day). Worse in a warm room, especially after being in open air (sixth day),.

Great pressure on the eyes, with muscae volitantes. The medicine affects the sight very much, producing these spectres constantly flitting before the sight.

long snakes or worms, both dark and light.

also waves before the eyes, giving objects a tremulous motion, as if it gave the same quality of involuntary motion to the optic nerve that it does to the motor nerves, and made the sight movable.

also a slight sensation of double sight, as if the images of objects would be multiplied (seventeenth day),.

If a very weak solution is used, so that the accommodation is not markedly affected, we find that on attempting to use binocular vision, as in reading, a disturbance exists, consisting of pain, blurring, and straining, so that one eye must be closed, which is relieved by a weak concave glass.

it seems as though the ordinary will, impulse, caused too great an action of the accommodation,.

Severe pains in the right eyeball, darting from within outward.

relief from pressing on the eyes.

the pain continued at intervals, from 6 1/2 to 10 P.M., when it seemed to shift to the supraorbital ridge, and continued till about 12 (after eleven hours and a half). As soon as I got up, at 7 A.M., experienced severe darting pains in both eyes.

pain darting outwards.

experienced no pain after breakfast.

as soon as I sat down to study, at 7 P.M., had the same darting pains in the left eye and superciliary ridge.

same character of pain, and relieved by pressure and moving about.

pain gradually diminished until 11 P.M. (second day),.

Pain, with sharp stitches, in the ball of right eye, and in the frontal bone, with a distinct pain running obliquely into the temporal bone, in the evening (first day). Pain deep, in over top of ball.

ran up from inner canthus to the right frontal eminence, then down obliquely outward into temple.

dull miserable pain. same in eye and forehead returned, not as severe, but more general over the forehead, relieved by motion out of doors (second day),.

On carefully watching the progress of the myosis (contraction of the pupil), the Irisis seen to contract convulsively with little jerks or twitches.

they are very small and rapid jerks, and would easily escape observation. While the Iriswas under the influence of Physostigma in all stages it was sensitive to light, that is, it would contract still more from a sudden strong light, even when the myosis had reached a high grade.

this seems to show that the sensibility of the retina remains unaffected. The myosis lasts from two to four days,.

Not only was the pupil of the healthy eye rapidly contracted, but even the paralyzed pupil, which, before the application, measured three and a half lines, was contracted to two-thirds of a line (the size of a pin's head), within half an hour after the instillation of the extract. The maximum of contraction of the pupil was the same in each eye, but the left regained its original size sooner.

it also always remained active under the influence of light, whereas the right was quite immovable. The sight of the right eye also rapidly improved, for within a quarter of an hour of the application she could read with it the very finest print, and this whilst its pupil was two and one-third lines in diameter. The effect upon the ciliary muscle was more marked in the left than in the right eye, for in the former the near point was approximated to three inches, the far point to five and a half inches.

in the right eye the near point was never brought closer than eight inches, nor the far point nearer than eleven inches. Stronger concave glasses were consequently required for distant objects by the left than by the right eye. The effect upon the accommodation also ceased much sooner in the right than in the left eye, for in the former the myopia had disappeared five hours after the application, whereas six days afterwards the sight of the left eye for distant objects was still improved by a concave glass of thirty-six inches focus,.

In a woman aged twenty-four, the sight of the right eye was so far impaired that she could only distinguish light from darkness, that pupil being very sluggish under the action of light, and much larger than its fellow. I applied a drop of the weakest solution between the lids of the right eye.

after half an hour the pupil had become so contracted that it was only about half the size of the other one. In an experiment on another woman, the pupil of the eye to which the solution was applied was contracted one-half after fifteen minutes. Third experiment a drop of the weak solution was applied between lids of right eye.

no visible change in the left pupil was perceptible (after eight minutes).

it had become slightly contracted (after twenty-three minutes).

contracted to half the size of its fellow (after twenty-six minutes).

it was less than half as large as its fellow (after twenty-eight minutes).

this pupil was only about equal to a pin's head in size, the pupil of the other eye having become larger than it had previously been (after thirty-three minutes).

Fourth experiment. I applied a drop of the weakest solution between the lids of the right eye.

no visible change (after eight minutes).

pupil contracted to the side of a pin's head (after twenty minutes).

very much contracted, but not to so great a degree as before (after nine hours).

still contracted, but almost as large as the other pupil (after twenty-one hours). The woman first mentioned had the stronger aqueous solution applied between the lids of the right eye.

the pupil was reduced to the size of a pin's head (after twenty-seven minutes). A woman of middle age had applied to left eye a drop of the weaker solution, now some days old.

no change (after sixteen minutes).

a drop of the stronger solution more recently made was applied.

in four minutes more the pupil was slightly contracted, and in twenty minutes still later very much so,.

Decidedly tight feeling, referable pretty accurately to the ciliary region of that eye, as if something were creeping about in it (after five minutes).

this continued with occasional rather sharp pains in the ciliary region (after ten minutes).

an attempt to read with both eyes instantly increased this pain, and the type was confused, as if by a disturbance of the power of accommodation.

The near point of the left eye (Jaeger, No. 1) was at six inches and three-quarters, that of the right eye being fifteen inches, thus indicating a spasm of accommodation in the left, and a diminished power in the right eye.

with this change, the effort to look at the type or optometer with either eye, or with both, much aggravated the sense of distress in the left eye.

the type looked smaller with the right eye than with the left.

the far point seemed the same as before in both eyes (after thirteen minutes).

I could see Jaeger 17 at fifteen feet, but with the left eye with a remarkable oscillation in the distinctness, so that the type came and went, at one instant quite clear, then indistinct, which coincided with the sensations present in the ciliary region, as if the ciliary muscle was undergoing irregular contractions.

the left pupil was now observed to have become rather suddenly contracted to the size of a large pin's head (after twenty minutes).

and to avoid repetition, I may state that this contraction continued to the full amount for eighteen hours, then gradually relaxed during about three days, after which it was like its fellow.

as it gradually dilated, it also resumed gradually its mobility under light, whether falling on its own or the opposite retina, or on both.

with the sudden contraction of the pupil came also a sudden twilight gloom, as of an eclipse of the sun, much more marked when the left eye only was open.

but this gloom soon lessened, owing, probably, to the retina, by continuance, becoming accustomed to the quantity of light admitted, and on the next day it was hardly noticeable.

The pupil being extremely small, we noted astigmatism.

the vertical bars of a window were seen clear and sharp at from six to ten feet, the horizontal bars within the same range having thin edges, slightly hazy, but rendered clear by a concave cylindrical glass of fourteen inches focus suitably placed.

distant objects seen by the left eye through a concave spherical glass of fifty inches focus were very decidedly diminished in size (after twenty-five minutes).

The near point by No. 1 Jaeger was for the left eye at six and a half inches, for the right eye only at ten and a half inches, not nearer or farther off, and even at this distance indistinct, whereas with the left eye the letters were crisp and clear.

to this better sight of the left eye two causes contributed the larger size of the retinal image, from the greater nearness of the type to the eye, and the smallness of the pupillary aperture.

with the left eye the near point for vertical lines was at eight and a half inches, for horizontal lines at six and a half inches.

with the right eye the near point for vertical lines was at eleven and a half inches, for horizontal lines at seven and a half inches (after thirty hours).

The strained feeling of the eye was less after half an hour, but did not quite cease until the next morning; the attempt to read continued painful all the evening and even next day both eyes were somewhat uneasy in sustained vision of near objects with both eyes or either of them.

Both eyes alike as to accommodation, and in both eye near point for vertical and horizontal lines was one inch nearer the eye than natural, viz., for horizontal lines near point seven inches, vertical lines near point nine inches.

and at twenty-four feet each eye could read No. 18 of Jaeger, only the letters were more sharply defined with the left, and looked rather smaller.

By way of comparison I accurately examined the accommodation for horizontal and vertical lines with each eye, and found both eyes alike.

the near point for horizontal lines being nine inches, for vertical lines ten inches for each, one inch more remote from the eye than after eighteen hours from the instillation of the solution of the bean (tenth day),.

Vision 1/2, with the use of a positive cylindrical glass 1/24 (hyperopic astigmatismus).

range of accommodation 1/5, 5 (before the experiment).

myopia 1/30. near point remains at 5 1/2 inches, though accommodation is reduced 1/6, 3/4 (after nine minutes). From this time the myopia gradually increases, and soon a slight nearing of the near point begins, with no trace of pain. Myopia 1/10.

near point 5 inches. accommodation only 1/10.

visual acuteness diminished to 2/3 (after twenty-two minutes).

Myopia 1/7, 1/2. near point, 4 3/4 inches.

accommodation only 1/13.

vision very indistinct at a distance, on account of large dispersion circles (after thirty-two minutes). Accommodation same.

myopia begins to diminish (after forty-four minutes). Accommodation 1/9.

myopia 1/10. near point the same (after forty-seven minutes). Accommodation 1/7.

myopia 1/16. near point a little farther (after fifty-two minutes). Accommodation 1/6.

myopia 1/24. near point 5 inches (after one hour and fourteen minutes). Accommodation 1/5, 1/2 (nearly normal).

near point 5 inches. myopia only 1/50 (after one hour and fifty-two minutes). The action on the ciliary muscle seems entirely independent of the presence of the Iris Versicolor ^iris. Slight biting in the conjunctiva, which passed off in a minute,.

When Atropine was first dropped into the eye (using a solution 4 grains to the ounce), in an hour and a half the nearest point was, left eight inches, right twelve inches.

then Physostigma was used, and in half an hour could only see distinctly between six and a half and nine inches.

after this Physostigma gradually predominated, and near vision became distinct,.

Objects distant more than one foot seem dim and indistinct.

all objects seemed nearer and larger.

pupils unchanged (after ten minutes).

pupils contracted to one line in diameter (normal size, two lines).

objects distant more than nine inches are dim.

all objects seem one-half larger and nearer (after twenty minutes).

pupil two-thirds of a line (the other pupil two and a half lines diameter).

no distinct vision beyond eight inches (after thirty minutes).

pupil one-half line (other pupil normal).

on reading, heaviness and fatigue of the eye.

dull aching and heaviness on using the eyes.

eyes feel strained (after seventy minutes). In a subsequent experiment, concave eight enabled him to see at a distance, but not nearer than five inches,.

Uncomfortable sensation in right ear.

felt inclined to bore in with the finger.

picked the ear and removed some wax, after which slight pain (after one hour and a half).

with eructation, a sudden pain running from the throat along the Eustachian tube to the middle, leaving a transient stabbing pain in the middle ear.

the pain to the ear repeated.

the uncomfortable sensation (desire to bore) occurred repeatedly for several successive evenings,.

Had a curious feeling in my face.

felt better when my mouth was open.

at times this feeling extended down into my neck.

I cannot describe it, but it seems to be of a cramping nature, or in spasms.

at the time when this was the worst, my left hand became quite numb, and it bothered me to hold on to anything.

this I noticed most when I went to look at my watch (fourth day),.

Physostigma evening (9 P.M.) my throat is very sore.

tonsils and soft palate inflamed, dark-red, with stinging pain (fifth day).

throat not so much inflamed (sixth day).

smarting of left tonsil (after a quarter of an hour).

left tonsil slightly inflamed.

radiating redness of tonsil (after half an hour, eighth day).

back part of throat very sore this evening (ninth day),.

A painful constriction of throat.

soreness felt all through the posterior portion of pharynx, with painful swallowing of saliva, at 7 P.M., throat became dry by 10 P.M. (fourth day). The pain and constriction of pharynx still continued, and examination showed small ulcers, with yellow centres, on right side of pharynx, behind tonsil.

posterior nares also dark-red, at 4 P.M. (fifth day). Throat very sore.

very difficult to swallow.

surface studded with fine ulcers, especially on right side, where the pain is greatest, from 4 to 10 P.M. (eighth day). Uvula considerably elongated, and though I have discontinued medicine for two or three days, the throat symptoms continue, though less violent (tenth day),.

As the fresh bracing air strikes me, a choking sensation, with fluttering of the heart (suffered frequently from this nervous affection between the age of sixteen and twenty) overcame me, and oppressed me during the whole forenoon.

I heard and felt the fluttering of my heart in the throat, with the sensation of faintness by motion, and some relief in a recumbent sitting position, not by lying down (Bromium ^Bromine without relief).

fluttering keeps steadily on, with attacks of vertigo, towards evening, especially when changing position.

heart's action irregular, thus about its action, --- --- ---, v v v, one, two, intermission.

one, two, three, intermission.

one, two, three, four.

the choking sensation in pit of the throat is steadily present.

sometimes it seems to me as if I could hear every artery of my body heat.

I took a dose of Sulphur ^Sulphur.

in about twenty minutes afterwards a severe aggravation set in.

I had to lean forward to catch my breath.

deep sighing relieved me.

hot sweat stood on my forehead.

my hands were cold and damp.

this lasted about a quarter of an hour, when the spasmodic action of the cardiac ganglia gradually ceased and I had a comfortable evening (fifth day). Heart's action still irregular, and sometimes tumultuous.

radial pulse weak, 75, every eight to ten minutes beat intermitting (sixth day),.

The pulse had been examined at different times within fifteen minutes and found to average 68 (before the experiment).

74 (after six minutes).

72 (after ten minutes).

72 (after thirty minutes).

76 (after fifteen minutes).

75 (after twenty minutes).

69 (after thirty-five minutes).

66 (after forty minutes).

68 (after forty-five minutes).

64 (after fifty minutes).

65, full and regular (after fifty-five minutes).

62, and rather feeble (after sixty minutes).

62 (after sixty-five minutes).

60, very small and wiry, but regular (after seventy minutes).

62 (after seventy-five minutes).

60, thready, and difficult to count (after eighty minutes).

60 (after eighty-five minutes).

58 (after ninety minutes).

59, very feeble, with occasional intermissions (after ninety-five minutes).

56 (after one hundred minutes).

56, thready and intermittent (after one hundred and five minutes).

58 (after one hundred and ten minutes).

60 (after two hours). 59 (after two hours, five minutes).

60, rather fuller (after two hours, ten minutes).

58 (after two hours, twenty minutes),.

Three calculations of the pulse within fifteen minutes gave an average of 74 per minute (before the experiment).

76 (after three minutes).

70 (after five minutes).

72 (after ten minutes).

66 (after fifteen and twenty minutes).

68, soft and compressible (after thirty minutes).

62 (after thirty-five minutes).

64 (after forty-five minutes).

58, and very feeble (after fifty-five minutes).

60 (after sixty-five minutes).

57 (after seventy-five minutes).

54, soft and compressible, and with occasional intermissions (after eighty minutes).

57 (after ninety-five minutes).

63, rather stronger (after two hours).

58 (after two hours, ten minutes).

continued to range between 60 and 70, till three hours after the commencement of the experiment,.

While taking usual morning cold bath, was suddenly seized with stiffness in right side of neck, which extended during the day to the right shoulder, and also to clavicle, which felt sore, and was swollen over sterno-mastoid muscle.

there was much pain from every attempt to move, and was relieved from leaning head towards right side.

this pain continued quite acute all day, extending towards evening through right lung also.

at times the pain in neck and shoulder was so severe as to cause nausea.

considerable sharp pain also in right ear (third day). Stiffness in neck and pain in ear almost entirely disappeared only a little soreness remained (fourth day). A little soreness still in muscles of neck (fifth day),.

In the afternoon, a peculiar pain across the back of the neck, I should say at the base of the brain, as if it were cutting off the body from the head.

it went right through the neck, and seemed to go to the back part of throat, which was stiff and sore.

a feeling of loss of power and sensation in the back of head, as if the head would fall over forward, and the natural supports of the head would no longer hold it back.

this was followed by pains all down the back of the neck, especially in the most prominent bone there, and on each side of it, drawing whenever the head was turned (fifth day),.

Felt slight contraction in region of stomach (second day).

contraction in region of stomach more plainly marked, continuing four or five days, attended with dull pain in left side and forepart of head.

not relieved by food. appetite as usual (after three days).

the symptoms began to diminish on the sixth day, and had disappeared about the eighth day,.

Epigastric sensation, accompanied with eructations (after five minutes).

slight sensation in the epigastric region (after fifteen minutes).

more intense and accompanied with eructations (after twenty minutes).

epigastric sensation recurs, without eructations (after thirty minutes).

sensations in epigastric region occur in quick succession (after fifty-five minutes),.

At 2 A.M. was awakened by a pressive pain in the epigastrium, just under the ensiform cartilage, extending up into the chest and down the arms.

pain in epigastrium seemed to be produced by hard pressure against the lower end of the sternum, and extended all along the lower edge of the ribs, at the attachment of the diaphragm, and through to the back to about the third dorsal vertebra.

the sensation was as if the pain was squeezed out into the arms.

the pain seemed to alternate between an ache and an acute quick pain, but was occasionally pulsative (after ten days),.

A slight degree of peculiar sensation in epigastrium (after ten minutes).

recurred (after forty minutes).

much increased. it now resembles the somewhat painful sensation which is produced when large pieces of food are suddenly swallowed, and recurs at intervals.

it is at first slightly indicated by a sensation in the thorax, near the upper part of the sternum.

this extends downwards, becoming more and more intense until it reaches the epigastrium, when it is almost painful, and eructations usually occur.

there is a distinct escape of gas, and this is followed by a reversal of the direction of the pain from the lower sternum to the throat, so that eructations occur at the middle of this sensation (after fifty minutes),.

Disgust for food, for tobacco, and coffee, and especially for cold drinks (I am a great water-drinker), (third day). There is not so much disgust for food, still I do not relish my usual cup of café au lait, and the toast remains untouched.

no appetite (fourth day). Ate some light breakfast from mere habit, but still no desire for food (fifth day). Ate a very light breakfast, with very little relish (sixth day),.

About 6 P.M., felt soreness in the umbilicus, and a sensation as though corset had pinched it.

on examination, about 8 P.M., found the part very much inflamed (blood-red), very sore, and could not bear the contact of the clothing (fourth day).

the following morning, inflammation somewhat decreased, but part still sore.

soreness and inflammation continued about four or five days, growing gradually less,.

Have had uneasiness in the abdomen all the morning, as though bowels were loose, and I should have colic.

have had similar symptoms within a week.

some uneasiness in the abdomen, as if the bowels were about to move, at 5.30 P.M.

there has been a remission of these feelings during the day.

at 8.30 P.M., rattling in the abdomen, with feeling as though the bowels were about to move, and that the stool would be diarrhoeic (second day),.

Woke about 4 A.M. with griping pain in bowels.

griping pains usually before the stools, but not much relieved by the stools, Veratrum Album ^Verat. alb. 30th, and old rye whisky failed to relieve.

at 10 A.M., a dry griping pain in the colon transversum (or stomach?), (third day).

slept moderately well, but the paroxysmal light gripes disturbed me.

as long as I lay on my right side, well covered up, I could rest and doze, but as soon as I turned on my back, the griping returned with full force, and was only relieved by turning on my right side again (third night). The least motion increases the dry griping pains in the upper part of the abdomen.

they differ somewhat from yesterday, as they extend to the back, causing there a lame sensation, as if support was needed.

towards evening the griping steadily increased (in spite of Dioscorea Villosa ^Dioscorea and Lilium), and the warmth of bed was early sought for relief (fourth day). The gripings continued the same till about 3 A.M. (relief by lying on right side, aggravation on back), when I rested more quietly till about 7 A.M.

off and on still griping pains (fifth day). Off and on the reminiscences of the old intestinal cramps, but no flatus (sixth day). Sometimes still some crampy sensation in pit of stomach (seventh day),.

Sphincter ani swollen and rigid.

evacuation painful. rectum protruding, swollen, and very sensitive (third day).

anus still very painful (fourth day).

hard lumps, like piles, protruding and very painful (fifth day).

piles worse, burning, and very sensitive.

used Cosmoline with excellent effect, as it quickly allayed the burning (sixth day).

piles better during the day.

at night the burning pain was so great, could get no rest till Cosmoline was applied, when I soon fell asleep (seventh day).

piles much worse. one large soft protuberance on the left side of anus, and two large hard lumps, that seem attached to the sphincter, on the right side.

they are dark-blue and very painful (eighth day).

piles very hard, protruding, and causing great pain, while sitting or walking.

the suffering was so great I took Physometra, 50 m. F.

shortly after taking it the pain and soreness lessened, and I slept well (ninth day).

found the pain all gone and the piles decreasing in size (tenth day).

had entirely disappeared (eleventh and twelfth days),.

A very copious stool, at 11 A.M.

passage from bowels of a yellowish color and soft consistency, at 3.30 P.M.

usually have but one passage from bowels each day, sometimes go two days.

evacuation of a foul smell, at 6.30 P.M.

stool at 10. 30 (second day).

stool at 6.30 A.M. (third day). Since proving, have been having two or three stools a day, at irregular times, not large, yellowish,.

From 5 A.M. to 9 A.M., had about eight to nine large watery stools.

the first ones mixed with fecal matter, the later ones light-yellow, watery, gushing out in a stream, with faint feeling, and cold sweat on the forehead.

griping pain usually before stool, but not much relieved by the stool.

the continual calls of nature drove me up, although the stools were, by 10 A.M., not more than a tablespoonful, and odorless (third day). Several times (two or three) a desire for stool, but only a small quantity of water escaped, and once some very foul-smelling flatus (fourth day). A bilious stool at 10 A.M. (fifth day),.

Soft, large, brown stool, at 7 A.M.

small thin yellow stool, smelling sour, at 2 P.M.

a small watery one, mixed with undigested food, smelling very sour, at 7 P.M.

small watery, at 10 P.M. (second day). Thin watery, with tenesmus afterwards, at 4 P.M. (third day). No stool (fourth day). Voided a large stool, part of which was natural looking, remainder black, like tar, at 7 A.M. (fifth day). Voided a natural-looking stool mixed with black lumps, followed by a small discharge of mucus, at 6 P.M. (sixth day). Small, thin, lumpy, stool.

tenesmus before and after stool, at 4.30 P.M. (seventh day). Small hard stool, covered with a jelly-like slime, at 7, and again at 7.30 A.M. (ninth day). Natural-looking stool, at 7 A.M. (tenth day),.

Bowels, which had been somewhat costive, moved twice, in the morning.

two soft stools after dinner, with tenesmus and dull pain in transverse and descending colon.

last stool fetid and brownish.

two stools in the evening, with similar pains and tenesmus during and after stool.

stools soft, brownish, and fetid, slight tenesmus of bladder at the same time (fourth day). Two soft mushy stools after breakfast, with same kind of pains.

same kind of stool and pain, and tenesmus of bladder, after dinner and supper (fifth day). Same kind of stool after breakfast, with tenesmus of rectum and bladder, during and after stool (sixth day). Constipation during the day I took none, and when I recommenced had four passages in one day, but not loose,.

No movement of bowels (second day).

desire several times without stool (third day).

one small hard stool (fourth day).

very copious discharge from bowels, light-colored, with intense crampy pain in lower part of bowels while at stool (not often), in the forenoon and again at 4 P.M. (fifth day).

had an operation from the bowels.

it was nearly impossible to pass stool owing to the contraction of the sphincter, at 8 P.M. (seventh day).

desire for stool early this morning, while in bed, with crampy pain in stomach, but after getting up the desire for stool left me (eighth day).

constipated (ninth day).

stool, with much urging, very hard and dark-colored.

pain in bowels during stool, at 9 A.M.

urging, with passages of stool much lighter than usual, at 9.05 A.M.

very copious diarrhoeic stool, yellow-colored, with burning-smarting pain (all three stools within fifteen minutes), (tenth day).

constipated (eleventh day),.

Had a natural stool, at 9.30 A.M.

one of softer consistency than natural at 11.40, another at 4.45 P.M. Desire for stool, but no stool, although I strained very hard, at 10.30 P.M. (second day). Operation of bowels at 6.15 A.M., of a slightly yellow color and foul smell.

soft consistency, at 2.10 P.M. (third and fourth days). Had been constipated very much for years.

no operation without injection. Have a desire for stool every night, and a copious evacuation every morning since the proving (fifth day),.

Stool neither hard nor soft, but dark and offensive, at 6.30 A.M.

discharge, with colic before and during stool, with some burning at the anus, at 9 A.M.

desire for stool, with rumbling in the bowels, at 3.40 P.M.

soft stool, with some colic before and during discharge, at 6.30 P.M.

large offensive stool, with some tenesmus, and slight colic before the discharge, at 10.15 P.M. (third day),.

Bowels constipated (third day).

have had no operation to-day (fourth day).

none to-day, but have urging without stool (fifth day).

desire without stool, at 9 A.M., and again at 11 A.M., with much urging and straining (sixth day).

operation from the bowels large, light-yellow color, and soft consistency, at 7 A.M.

operation of bowels, soft consistency, at 9 A.M.

desire, without stool, at 12 M. and 7.30 P.M. (seventh day).

operation from bowels, at 7.30 A.M.

stool, with much straining to pass a small amount, at 2.30 P.M. (eighth day).

desire for stool early this morning, with large stool of light-yellow color (ninth day).

bowels constipated (tenth day).

no stool (eleventh day).

several operations from bowels (soft consistency).

(twelfth day). three passages from bowels (thirteenth day),.

The quantity of urine passed is slightly increased (second day).

increased and of a pale yellow color, all day (third day).

urine increased in quantity, and contains mucus.

number of passages of urine increased.

yellow color of urine.

the amount of urine passed is greater than the amount of fluid I drink (fourth day).

urine scanty (seventh day).

passed a large amount of yellowish-colored urine containing mucus (ninth day),.

Deep pain in muscles of right forearm and wrist came on about 8 P.M., and with it a dull aching pain at times occurred (first day). Pain moving.

gnawing in inner aspect of wrist, deeply situated.

from wrist it ran up along ulnar side of forearm to elbow.

had a desire to move the arm and work it out, which did not relieve (second day),.

On walking, feeling of unsteadiness from knees downwards, so that he had to tread carefully, especially when eyes are shut.

feels as if he must look to see where he is going. On going out in open air must take a stick to steady himself, and has a feeling of weakness about the ankles. Determined exertion of the will relieves the unsteadiness (second day),.

Irresistible desire to sleep.

soporific sleep, extremely distressing, with the headache (second day).

felt drowsiness and desire to sleep all the forenoon, even while driving.

after dinner the drowsiness, instead of passing off by exercise, increased, and for two hours he slept soundly, without dreams, in an uncomfortable position.

he could arouse himself only with great effort.

the sleepiness continued for an hour, even while walking in clear, cool air and bright sunlight.

slept well all night (this is never the case after having even a short nap in the afternoon), (third day). He awoke at 6 A.M., and felt bright for two hours, when he became sleepy again while driving, with dull pressure encircling the head.

after a light dinner, sleepiness became irresistible, and he slept some time.

went to bed early and slept well (third day).

drowsiness all the day, until after two hours' work in the garden, causing profuse perspiration, which expelled the drowsiness in part (fourth day).

felt it slightly (fifth day),.

Felt sleepiness while riding, for two mornings.

after dinner he felt great drowsiness, which was very difficult to shake off.

his desire for sleep was uncontrollable.

he would fall asleep so quickly that he was surprised on waking up that he had slept.

a few hours of hard exercise would remove the drowsiness.

he slept just as well at night as if he had not slept in the afternoon,.

Trembling of legs, as if I could not walk straight, at 7.30 A.M. Seized with violent trembling all over, in the street, at 9.30 A.M. Felt for an instant as if I should lose consciousness, and could hardly get home.

riding in a car for twenty minutes did not relieve the sensations.

these trembling spells came on in fits, and at the least thing that startles.

at 10.30 A.M. trembling of hands, so that I could hardly sew.

this spell lasted an hour, when the soreness at the pit of the stomach came on (seventeenth day),.

Almost instantly felt a shuddering and trembling run down through all the nerves of the body.

General weariness of whole body.

easily exhausted upon going upstairs.

greatly exhausted after a stool (third day). Very weak, especially in groins, at 9 A.M.

some weakness of body, and easily exhausted, at 9 P.M. (fourth day). A little weak (fifth day). Easily exhausted (sixth day). General weakness and tired feeling.

weakness after stool. great weakness of right side (eighth day). Great weakness and stupidity.

feel as if I had been out carousing the night previous (or as those feel who do go out carousing at night), (ninth day). Some weakness, at 9 A.M.

tired feeling, at 10 P.M. (tenth day). Easily exhausted (eleventh day). Some exhaustion on walking (twelfth day),.

I tried to raise myself on my elbow to vomit, but failed.

I made a second, more vigorous, effort, but scarcely moved.

at once it struck me, "This is not debility, but volition is inoperative;" in a third effort I was more nearly successful, and in the fourth, a resolute exercise of the will, I did succeed, but could not vomit.

the abdominal muscles acted too feebly, nor were they much aided by a voluntary effort to make them act (after 12 grains),.

Felt completely prostrated and obliged to lie down, at 10 A.M.

only wanted to be let alone, be well covered with woollen blankets, shut my eyes, and doze away the time, at noon (third day). All I wish is to rest and sleep, if the gripes would only allow it (fourth day). As the day wore on a general prostration set in again, as if my feet were too weak to hold me up.

reading was tiresome, and speaking an effort.

I tried to walk out, but had to five up on account of general prostration and soreness of bowels, produced by the motion (sixth day),.

In the first action of the medicine, all the symptoms run through two days, with one exception, that of soreness in the tongue and difficulty of moving it.

the medicine has begun a second round or course, which has been much longer (third day). All the symptoms are more decided, distinct, and prolonged than the first time, and the medicine seems to act more searchingly than in the first round, although the dose has not been repeated (fifth day),.

The chief action of this medicine seems to me to be in the nerves.

all the other symptoms have been entirely accessory and secondary.

and it seems to me, so far as I can judge, to have a very curious double action on the nervous system.

the nerves in front of the body (which I believe are the ?? voluntary nerves, or ?? nerves of motion), it appears to excite to involuntary motion, causing tremblings, and going up and down in wavelike motion, all down through.

but the nerves in the back of the body (the ?? passive nerves or nerves of ?? sensation), it seems to paralyze and numb, and during this numbing process it causes a good deal of pain, very similar to a pain in a tooth when its nerve is dying or being killed,.

Physostigma and its active principle, Eserine, form a valuable addition to Materia Medica. Stimulates heart, raises blood pressure, and increases peristalsis. Causes contraction of the pupil and of the ciliary muscles. Induces a condition of short-sightedness. Spinal irritation, loss of motility, prostration, with very sensitive vertebrae. Fibrillary tremors. Rigidity of muscles; paralysis. Depresses the motor and reflex activity of the cord and causes loss of sensibility to pain, muscular weakness, followed by complete paralysis, although muscular contractility is not impaired. Paralysis and tremors, chorea. Meningeal irritation, with rigidity of muscles. TETANUS and trismus. Poly myelitis anterior. Eserine is used locally to produce contraction of pupil.

Weakness; muscles won't respond or draw into knots; worse cold

Weakness in lower limbs; coming from a spot between hips

Cramp in left calf at night in bed

Shuddering, worse every draft

Horror of cold water Averse to bathing

Active mind, even during sleep

Floating sensation

Nothing seems right

Brain falls to side lain on

Pains from forehead down nose

Sensation as of a tight cap on head

Vertigo; stumbles on ascending or descending steps

Sensation as of a band about head

Twitching of eye muscles or of nose Can't bear to raise eyelids

Accommodation affected

Seems to have swallowed a lump

Torpid bowels

Numb womb

Flushes of heat, worse in palms

Sore bloated, red navel; hypogastrium, worse standing

Tremor; in head, eyes, vision, nose, teeth, muscles, etc

Dartings, here and there

Tense eye-lids, can't open or close them

Blood-shot eyes

Creeping numbness from occiput down spine

Licks lips

Teeth feel rough

Tongue feels oily; scalded

Loose skin feeling in roof of mouth

Thick, leathery saliva

Hic-cough with short breath

Gripe in right hypochondrium

Groins pain alternately

Abdomen, better extending legs

Numbness at womb

Offensive odor from hands

Sweat in excitement

Heart seems to flutter in throat or over body

Sensitive spine Jerking limbs

Shudders from every draft of air

Attacks of overpowering sleepiness, with feeling as if to lose consciousness

Physostigma venenosum. Calabar Bean. Eséré. N. O. Leguminosae. Trituration of the bean.

Astigmatism. Bathing, effects of. Blepharospasm. Chorea. Ciliary spasm. Climacteric. Constipation. Coccygodynia. Dentition. Diarrhoea. Dyspepsia. Epilepsy. Eyes, affections of.

injuries of. strain of. General paralysis. Glaucoma. Haemorrhoids. Headache. Heart, affections of. Hemiplegia (l.) Herpes, preputialis. Hiccough. Hysteria. Iris Versicolor ^Iris, prolapsed. Leucorrhoea. Levitation. Locomotor ataxy. Myopia. Navel, inflammation of. Paralysis, local.

agitans. spinal. Paraplegia. Progressive muscular atrophy. Prostration.

muscular. Sleeplessness. Spinal irritation. Spinal sclerosis. Stiff neck. Tetanus. Throat, sore.

fish-bone sensation. Water, effects of. Wounds.

"The Ordeal-bean" of Old Calabar, the Eséré of the natives, is the type of a genus of Leguminosae of the tribe Phaseoleae, with flowers very like Phaseolus, except that its bearded style is terminated by a great oblique hood, covering the blunt stigma." It is this hood which distinguishes the genus and gives it its name.

P. ven. is a great twining climber, and has purplish flowers.

Its seeds are very poisonous, and are used by the Calabari as an ordeal, suspected persons being compelled to eat them until they either vomit or die.

In the latter case they are considered guilty, in the former innocent.

A number of cases of poisoning have occurred in this country, and in these the most notable feature was complete muscular prostration.

According to Brunton, the tetanising properties of the bean belong to an alkaloid, Calabarine, and the paralysis to Eserine (or Physostigmine, as it is now called).

The paralysis is seated in the spinal cord itself.

The muscles are affected by fluttering tremors; involuntary muscles are excited to active movements and expulsive efforts.

The intestines are often twisted up in knots.

All the secretions are somewhat increased (C. D. P.).

A crowd of children in Liverpool ate beans which they found among the sweepings of a ship from Africa.

Forty-six were admitted to hospital with loss of muscular power, prostration, feeble, slow pulse, cold, perspiring skin, cold extremities; vomiting in nearly all cases, diarrhoea in one-third of them.

At first there was colic, but later on remarkable freedom from pain.

Pupils contracted in many; in one contracted during sleep, dilated when aroused.

Only one (a phthisical boy) succumbed.

He staggered as he walked, then fell, kicking and rolling as if in pain, but afterwards became quiet; much purged; pulse hardly perceptible; skin cold, face livid; quite conscious and able to swallow water.

Directly after drinking he died without a struggle, some froth issuing from nose and mouth.

Many excellent provings have been made with Physo., among which one made by Christison on himself is remarkable.

Simpson and Douglas MacLagan were sent for to attend him in his collapsed state, which Simpson could only compare to that produced by severe flooding, though Christison's only sensation was one of "extreme but not unpleasant faintness." MacLagan thought it like Aconite ^Aconite poisoning.

Christison could not get his will into his muscles except by a tremendous effort.

Warmth to feet and a sinapism to whole abdomen gave great relief, and he was then able to turn on his left side; but only remained there a very short time on account of the tumultuous action of the heart it set up.

He became drowsy and slept; but his mind was so active in sleep that on awaking he did not know that he had slept.

The tumultuous action of the heart continued on waking, but strong coffee quickly restored the whole condition and made the heart regular.

A symptom observed by Christison and many other provers was one of indigestion, "as if large pieces of food had been suddenly swallowed." It began under upper sternum, descending and increasing in intensity till it reached the epigastrium.

eructations then occurred, and a reversal of direction followed, the sensation ending where it began.

With other provers there was a sensation of weight and hardness.

Christison also had very much giddiness and dimness of vision.

It is for its action on the eye, especially for its power of contracting the pupil, and thereby antagonising Atropine, that Physo. and its alkaloid Eserine are best known in old-school practice.

The effects are more definite when the drug (tincture, extract, or solution of alkaloid) is applied to the eye direct; but one myopic prover had his myopia much diminished.

In glaucoma it has been used with signal success to diminish intra-ocular tension; and especially when glaucoma has been the result of injury.

Dudgeon (B. J. H., xxxviii. 60) relates the case of A. E., 26, struck by the cork of a soda-water bottle on inferior and outer part of left eyeball.

Intense burning pain and effusion into the eyeball followed.

Under Arnica ^Arn., prescribed by Mr.

Engall, the effusion disappeared, and later the pain and inflammation subsided under Aconite ^Aco. and Merc Viv ^Merc. c. The pupil was now egg-shaped, the long diameter perpendicular, smaller end downwards.

vision extremely myopic. Belladonna ^Bell. dilated the pupil, but had no effect on the vision.

Engall sent the patient to Dudgeon, who found the pupil was sluggish, and a book had to be held within four inches of the eye to be read.

Physo. 3x, every three hours, was given.

After the first dose objects could be seen at a considerable distance, and next day sight was nearly as good as ever.

Dudgeon considers that the lens was tilted by the blow, and that Physo. restored the over-stretched or paralysed portion of the ciliary muscle.

Woodyatt (Org. iii. 99) states that Physo. has produced corneal astigmatism in a young lady, who found any attempt at close work caused redness of tarsal edges and a hot, sandy feeling in conjunctiva. Lil. t. 30 cured.

Paralysis and tremors predominate over the cramps, twitchings, stiffnesses, and tension of Physo., but these are also characteristic, and tetanus has been cured by Physo.

Paralysis of left side is very proeminent, and the numbness is more apparent on left side, especially in left arm; which may be associated with heart symptoms.

The apex of the left lung is also affected.

A feeling of levitation was observed in one prover on stepping.

Ataxic gait and shooting pains down limbs show its appropriateness in locomotor ataxy.

The inability to get the will into the muscles is a striking feature of many paralyses.

Spinal, sacral, and coccygeal pains were experienced, and associated with some of them, numbness of the womb.

The association of muscular prostration (in any form, of which laboured respiration is one) with any affection is a keynote of Physo.

Physostigma case was cured Great muscular prostration with continual inclination to sigh; leucorrhoea agg. by exercising during the day, especially 4 p.m.; sighing agg. when leucorrhoea is agg.; dread of cold water.

Physostigma dread of cold water is a grand keynote of Physo.

One of the provers (a water drinker) developed a perfect disgust for cold water and cold drinks; and though used to a cold morning plunge, was obliged to omit it on account of his horror.

Other provers felt uncomfortable after bathing, and had great reluctance to their bath.

Weakness was felt on change of weather, and on cold, bracing days.

A paralytic state of mind and body from grief has been cured with Physo.

Sleeplessness of a peculiar kind occurs in Physo.

Nash (Med. Adv., xx. 258) cured with Physo. 12 and 30 persistent sleeplessness in a patient who had been in an insane asylum, and feared she would have to go again.

Her symptom was "If she chanced to get a nap she awoke suddenly as if in a fright, and felt no amel. from what she had slept." Peculiar sensations are As if stomach were full.

As if she must lose her mind.

As if a ball were coming up throat.

Lower limbs as if asleep.

Back as if paralysed. Tongue as if burnt (left margin); as if swollen and paralysed.

Sensations of contraction and tension.

Wavering in brain. Weak feeling in stomach.

H. L. Chase, one of the provers, had a "very severe pain in the right popliteal space," and he afterwards cured a patient who came to him with pain in the same region two years later (H. R., xiii. 117). (Allen gives the symptom as in the left popliteal space.) The symptoms are agg. by pressure (of finger between vertebrae causing wincing).

by falls and blows. agg.

Motion; descending stairs (wavering in brain). agg.

Walking; stepping; jar of misstep. amel.

Lying supine. agg. Lying l. side; amel. lying on r. side. agg. 4 p.m. agg.

Night (headache unbearable).

If pain began at any hour it always continued till 12 o'clock following, either noon or midnight. agg.

Cold water; perfect horror of cold drink; cold bath. agg.

From bathing; from change in weather; on bracing days. agg.

In church. amel. In cool open air. agg.

On waking. amel. Closing eyes. amel.

By sleep (hiccough). amel.

Warmth to feet; sinapisms to abdomen.

Pain over r. eye, in morning on waking, by noon pain in whole cerebrum, fulness of blood-vessels of brain, and contracted feeling in forehead, which extended to eyelids, causing an effort to open or close them.

in l. side at 10 a.m., with heat in abdomen and nausea, the pain is heavy at 11, pain over whole head from 4 till 10 p.m., with nausea and general sweat, headache next day with lame, bruised feeling in region of kidneys.

Dose

Third potency. The neutral sulphate of Eserine is instilled into the eye, from one-half to four grains to one ounce distilled water, to induce Contraction of pupil, in mydriasis, injuries to the eye, iritis, corneal ulcers

Region

Spinal motor nerves

Eyes

Muscles

Left side